We develop instrumentation and workflows that reveal where molecules are located within tissues and samples, building chemical images that connect molecular composition to biological structure. This spatial view of metabolites and lipids underpins our work in cancer biology and spatial omics.
Selected publications
All publications→- 2025
A Spatial Metabolomics Annotation Workflow Leveraging Cyclic Ion Mobility and Machine Learning-Predicted Collision Cross Sections
Dmitry Leontyev, Eric C. Gier, Viraj A. Master, Rebecca S. Arnold, John A. Petros, Facundo M. Fernández. J. Am. Soc. Mass Spectrom. 2025, 36, 6, 1386–1394
- 2024
Desorption Electrospray Ionization Cyclic Ion Mobility-Mass Spectrometry Imaging for Traumatic Brain Injury Spatial Metabolomics
, Dmitry Leontyev, Hernando Olivos, Bindesh Shrestha, Pooja M. Datta Roy, Michelle C. LaPlaca, Facundo M. Fernández. Anal. Chem. 2024, 96, 33, 13598–13606
- 2024
Investigation of MSC potency metrics via integration of imaging modalities with lipidomic characterization
, Priyanka Priyadarshani, Alexandria Van Grouw, Adrian Ross Liversage, Kejie Rui, Arina Nikitina, Kayvan Forouhesh Tehrani, Bhavay Aggarwal, Steven L. Stice, Saurabh Sinha, Melissa L. Kemp, Facundo M. Fernandez, and Luke J. Mortensen. Cell Reports, 2024, 43(8), 114579
- 2024
Applications of MALDI mass spectrometry in forensic science
, Camila M. de Almeida, Valdemar Lacerda Jr., Xin Ma, Facundo M. Fernández, Nayara A. dos Santos, and Wanderson Romão*. Anal. Bioanal. Chem., 2024, 416, 5255–5280
- 2024
Spatial Lipidomics Maps Brain Alterations Associated with Mild Traumatic Brain Injury
Dmitry Leontyev, Alexis Pulliam, Xin Ma, David A. Gaul, Michelle LaPlaca*, Facundo M. Fernández*, Front. Chem., 2024, 11, 1332816
- 2024
Ultrahigh Resolution Lipid Mass Spectrometry Imaging of High-Grade Serous Ovarian Cancer Mouse Models
Xin Ma, Andro Botros, Sylvia R. Yun, Eun Young Park, Olga Kim, Ruihong Chen, Murugesan Palaniappan, Martin M. Matzuk, Jaeyeon Kim*, Facundo M. Fernández*, Front. Chem., 2024, 11, 1332816
- 2023
Mass spectrometry imaging reveals early metabolic priming of cell lineage in differentiating human induced pluripotent stem cells
, Arina A. Nikitina, Alexandria Van Grouw, Tanya Roysam, Danning Huang, Facundo M. Fernández, Melissa L. Kemp*, Anal. Chem. 2023, 95, 11, 4880–4888
- 2020
A Co-registration Pipeline for Multimodal MALDI and Confocal Imaging Analysis of Stem Cell Colonies
, Arina Nikitina, Danning Huang, Li Li, Nicholas Peterman, Sarah Seals, Facundo M. Fernández*, Melissa L. Kemp*, J. Am. Soc. Mass Spectrom. 2020, 31, 4, 986–989.
- 2019
Three-Dimensional Mass Spectrometry Imaging Identifies Lipid Markers of Medulloblastoma Metastasis
. Martin R. L. Paine, Jingbo Liu, Shane Ellis, Dennis Trede, Jan H. Kobarg, Ron M.A. Heeren*, Facundo M. Fernández*, Tobey J. MacDonald*, Sci. Rep., 2019, 9(1):2205.
- 2018
Correlated Materials Characterization via Multimodal Chemical and Functional Imaging
, Alex Belianinov, Anton V. Ievlev, Matthias Lorenz, Nikolay Borodinov, Benjamin Doughty, Facundo M. Fernández, Olga S. Ovchinnikova. ACS Nano, 2018, 12(12):11798-11818
- 2018
Robotic Surface Analysis Mass Spectrometry (RoSA-MS) of Three-Dimensional Objects
, Anyin Li, Martin R. L. Paine, Stephen Zambrzycki, Rachel V. Stryffeler, Jason Wu, Marcos Bouza, Jake Huckaby, Chu-Yin Chang, Manoj Kumar, Piyoosh Mukhija, Facundo M. Fernández*, Anal. Chem., 2018, 90, 3981-3986
- 2017
Visualizing Molecular Distributions for Materials Chemistry Applications with Mass Spectrometry Imaging: A Review
, Martin R. L. Paine, Peter Kooijman, Ron M. Heeren, Facundo M. Fernández, Shane R. Ellis*. J. Mat. Chem. B., 2017, 5, 7444-7460
+ 13 more in this area on the publications page.