Exercise Multi-omics (MoTrPAC)

Molecular Transducers of Physical Activity Consortium (MoTrPAC): human studies design and protocol

MoTrPAC Study Group, Jakicic JM, Kohrt WM, et al., J. Appl. Physiol., 2024;137(3):473-493.

Molecular adaptations in response to exercise training are associated with tissue-specific transcriptomic and epigenomic signatures

Venugopalan D. Nair, Hanna Pincas, Archana Natarajan Raja, Gregory R. Smith, Elena Zaslavsky, Yongchao Ge, Mary Anne S. Amper, Mital Vasoya, Yifei Sun, Maria Chikina, Weiguang Mao, Nicole R. Gay, Karyn A. Esser, Kevin S. Smith, Bingqing Zhao, Laurens Wiel, Aditya Singh, Stephen Montgomery, Malene E. Lindholm, David Amar, Michael P. Snyder, Martin J. Walsh, Stuart C. Sealfon, and the MoTrPAC Study Group, Cell Genom., 2024, 4(6), 100421

Temporal dynamics of the multi-omic response to endurance exercise training

, MoTrPAC Study Group, David Amar, Nicole R. Gay, Pierre M. Jean Beltran, Joshua N. Adkins, Jose J. Almagro Armenteros, Euan Ashley, Julian Avila-Pacheco, Dam Bae, Nasim Bararpour, Charles Burant, Clary Clish, Gary Cutter, Surendra Dasari, Courtney Dennis, Charles R. Evans, Facundo M. Fernández, David Gaul, Yongchao Ge, Robert Gerszten, Laurie J. Goodyear, Zhenxin Hou, Olga Ilkayeva, Anna A. Ivanova, David Jimenez-Morales, Maureen T. Kachman, Hasmik Keshishian, William E. Kraus, Ian R. Lanza, Jun Li, Malene E. Lindholm, Ana C. Lira, Gina M. Many, Shruti Marwaha, Michael E. Miller, Michael J. Muehlbauer, K. Sreekumaran Nair, Venugopalan D. Nair, Archana Natarajan Raja, Christopher Newgard, Eric A. Ortlund, Paul D. Piehowski, David M. Presby, Wei-Jun Qian, Jessica L. Rooney, James A. Sanford, Evan Savage, Stuart C. Sealfon, Gregory R. Smith, Kevin S. Smith, Alec Steep, Cynthia L. Stowe, Yifei Sun, Russell Tracy, Nikolai G. Vetr, Martin J. Walsh, Si Wu, Tiantian Zhang, Bingqing Zhao, Jimmy Zhen, Brent G. Albertson, Mary Anne S. Amper, Ali Tugrul Balci, Marcas Bamman, Elisabeth R. Barton, Bryan Bergman, Daniel Bessesen, Frank Booth, Brian Bouverat, Thomas W. Buford, Tiziana Caputo, Toby L. Chambers, Clarisa Chavez, Maria Chikina, Roxanne Chiu, Michael Cicha, Paul M. Coen, Dan Cooper, Elaine Cornell, Karen P. Dalton, Luis Oliveria De Sousa, Roger Farrar, Kishore Gadde, Nicole Gagne, Bret H. Goodpaster, Marina A. Gritsenko, Kristy Guevara, Fadia Haddad, Joshua R. Hansen, Melissa Harris, Trevor Hastie, Krista M. Hennig, Steven G. Hershman, Andrea Hevener, Michael F. Hirshman, Fang-Chi Hsu, Kim M. Huffman, Chia-Jui Hung, Chelsea Hutchinson-Bunch, Bailey E. Jackson, Catherine Jankowski, Christopher A. Jin, Neil M. Johannsen, Benjamin G. Ke, Wendy M. Kohrt, Kyle S. Kramer, Christiaan Leeuwenburgh, Sarah J. Lessard, Bridget Lester, Xueyun Liu, Ching-ju Lu, Nathan S. Makarewicz, Kristal M. Maner-Smith, DR Mani, Nada Marjanovic, Andrea Marshall, Sandy May, Edward Melanson, Matthew E. Monroe, Ronald J. Moore, Samuel Moore, Kerrie L. Moreau, Charles C. Mundorff, Nicolas Musi, Daniel Nachun, Michael D. Nestor, Robert L. Newton Jr., Barbara Nicklas, Pasquale Nigro, German Nudelman, Marco Pahor, Cadence Pearce, Vladislav A. Petyuk, Hanna Pincas, Scott Powers, Shlomit Radom-Aizik, Krithika Ramachandran, Megan E. Ramaker, Irene Ramos, Tuomo Rankinen, Alexander (Sasha) Raskind, Blake B. Rasmussen, Eric Ravussin, R. Scott Rector, W. Jack Rejeski, Collyn Richards, Stas Rirak, Jeremy M. Robbins, Aliza B. Rubenstein, Frederique Ruf-Zamojski, Scott Rushing, Tyler J. Sagendorf, Mihir Samdarshi, Irene E. Schauer, Robert Schwartz, Nitish Seenarine, Tanu Soni, Lauren M. Sparks, Christopher Teng, Anna Thalacker-Mercer, John Thyfault, Rob Tibshirani, Scott Trappe, Todd A. Trappe, Karan Uppal, Sindhu Vangeti, Mital Vasoya, Elena Volpi, Alexandria Vornholt, Michael P. Walkup, John Williams, Ashley Xia, Zhen Yan, Xuechen Yu, Chongzhi Zang, Elena Zaslavsky, Navid Zebarjadi, Sue C. Bodine, Steven Carr, Karyn Esser, Stephen B. Montgomery, Simon Schenk, Michael P. Snyder, Matthew T. Wheeler, MoTrPAC Study Group, Nature, 2024, 629, 174-183 [Large scale multi-omics study on the effects of physical activity in animals (1% contribution)] Featured on the Journal cover

Physiological Adaptations to Progressive Endurance Exercise Training in Adult and Aged Rats: Insights from the Molecular Transducers of Physical Activity Consortium (MoTrPAC)

Simon Schenk, Tyler J. Sagendorf, Gina M. Many, Ana K. Lira, Luis G.O. de Sousa, Dam Bae, Michael Cicha, Kyle S. Kramer, Michael Muehlbauer, Andrea L. Hevener, R. Scott Rector, John P. Thyfault, John P. Williams, Laurie J. Goodyear, Karyn A. Esser, Christopher B. Newgard, Sue C. Bodine, The MoTrPAC Study Group. Function, 2024, 5(4) zqae014.

The mitochondrial multi-omic response to exercise training across tissues

David Amar, Nicole R Gay, David Jimenez-Morales, Pierre M Jean Beltran, Megan E Ramaker, Archana Natarajan Raja, Bingqing Zhao, Yifei Sun, Shruti Marwaha, David A Gaul, Steven G Hershman, Alexis Ferrasse, Ashley Xia, Ian Lanza, Facundo M Fernández, Stephen B Montgomery, Andrea L Hevener, Euan A Ashley, Martin J Walsh, Lauren M Sparks, Charles F Burant, R Scott Rector, John Thyfault, Matthew T Wheeler, Bret H Goodpaster, Paul M Coen, Simon Schenk, Sue C Bodine, Malene E Lindholm, Joshua N Adkins, Jose Juan Almagro Armenteros, Mary Anne S Amper, Dam Bae, Marcas Bamman, Nasim Bararpour, Jerry Barnes, Bryan C Bergman, Daniel H Bessesen, Nicholas T Broskey, Thomas W Buford, Steven Carr, Toby L Chambers, Clarisa Chavez, Roxanne Chiu, Natalie Clark, Gary Cutter, Charles R Evans, Edziu Franczak, Nicole Gagne, Yongchao Ge, Krista M Hennig, Joseph A Houmard, Kim M Huffman, Chia-Jui Hung, Chelsea Hutchinson-Bunch, Olga Ilkayeva, Bailey E Jackson, Catherine M Jankowski, Christopher A Jin, Neil M Johannsen, Daniel H Katz, Hasmik Keshishian, Wendy M Kohrt, Kyle S Kramer, William E Kraus, Bridget Lester, Jun Z Li, Ana K Lira, Adam Lowe, DR Mani, Gina M Many, Sandy May, Edward L Melanson, Samuel G Moore, Kerrie L Moreau, Nicolas Musi, Daniel Nachun, Venugopalan D Nair, Christopher Newgard, German Nudelman, Paul D Piehowski, Hanna Pincas, Wei-Jun Qian, Tuomo Rankinen, Blake B Rasmussen, Eric Ravussin, Jessica L Rooney, Scott Rushing, Mihir Samdarshi, James A Sanford, Irene E Schauer, Stuart C Sealfon, Kevin S Smith, Gregory R Smith, Michael Snyder, Cynthia L Stowe, Jennifer W Talton, Christopher Teng, Anna Thalacker-Mercer, Russell Tracy, Scott Trappe, Todd A Trappe, Mital Vasoya, Nikolai G Vetr, Elena Volpi, Michael P Walkup, Laurens Wiel, Si Wu, Zhen Yan, Jiye Yu, Elena Zaslavsky, Navid Zebarjadi, Jimmy Zhen, Cell Metabolism, 2024, 36(6), 1411-1429

The impact of exercise on gene regulation in association with complex trait genetics

, Nikolai G. Vetr, Nicole R. Gay, MoTrPAC Study Group, Stephen B. Montgomery. Nat. Commun., 2024, 5, 3346.

Sexual dimorphism and multi-omic response to exercise training in rat subcutaneous white adipose tissue

, The MoTrPAC Study Group, Nat. Metab., 2024, 6, 963–979.

Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise

, James A. Sanford, Christopher D. Nogiec, Joshua N. Adkins, David Amar, Surendra Dasari, Jonelle K. Drugan, Charles R. Evans, Facundo M. Fernández, Yafeng Li, Malene E. Lindholm, Shlomit Radom-Aizik, Simon Schenk, Michael P. Snyder, Russell P. Tracy, Patrick Vanderboom, Scott Trappe, Martin J. Walsh*, Cell, 2020, 181(7), 1464-1474.